Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.
Publication
, Journal Article
Bejsovec, A; Anderson, P
Published in: Cell
January 1990
We have determined the positions and sequences of 31 dominant mutations affecting a C. elegans muscle myosin heavy chain gene. These mutations alter thick filament structure in heterozygotes by interfering with the ability of wild-type myosin to assemble into stable thick filaments. These assembly-disruptive mutations are missense alleles affecting the globular head of myosin. The most strongly dominant alleles alter highly conserved residues of the myosin ATP binding site, indicating that functions of the myosin ATPase are important for thick filament assembly. Other alleles alter the site at which myosin binds actin.
Duke Scholars
Published In
Cell
DOI
EISSN
1097-4172
ISSN
0092-8674
Publication Date
January 1990
Volume
60
Issue
1
Start / End Page
133 / 140
Related Subject Headings
- Myosins
- Myosin Subfragments
- Mutation
- Muscles
- Molecular Sequence Data
- Genes
- Gene Amplification
- Developmental Biology
- Cytoskeleton
- Codon
Citation
APA
Chicago
ICMJE
MLA
NLM
Bejsovec, A., & Anderson, P. (1990). Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. Cell, 60(1), 133–140. https://doi.org/10.1016/0092-8674(90)90723-r
Bejsovec, A., and P. Anderson. “Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.” Cell 60, no. 1 (January 1990): 133–40. https://doi.org/10.1016/0092-8674(90)90723-r.
Bejsovec A, Anderson P. Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. Cell. 1990 Jan;60(1):133–40.
Bejsovec, A., and P. Anderson. “Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.” Cell, vol. 60, no. 1, Jan. 1990, pp. 133–40. Epmc, doi:10.1016/0092-8674(90)90723-r.
Bejsovec A, Anderson P. Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. Cell. 1990 Jan;60(1):133–140.
Published In
Cell
DOI
EISSN
1097-4172
ISSN
0092-8674
Publication Date
January 1990
Volume
60
Issue
1
Start / End Page
133 / 140
Related Subject Headings
- Myosins
- Myosin Subfragments
- Mutation
- Muscles
- Molecular Sequence Data
- Genes
- Gene Amplification
- Developmental Biology
- Cytoskeleton
- Codon