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Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.

Publication ,  Journal Article
Bejsovec, A; Anderson, P
Published in: Cell
January 1990

We have determined the positions and sequences of 31 dominant mutations affecting a C. elegans muscle myosin heavy chain gene. These mutations alter thick filament structure in heterozygotes by interfering with the ability of wild-type myosin to assemble into stable thick filaments. These assembly-disruptive mutations are missense alleles affecting the globular head of myosin. The most strongly dominant alleles alter highly conserved residues of the myosin ATP binding site, indicating that functions of the myosin ATPase are important for thick filament assembly. Other alleles alter the site at which myosin binds actin.

Duke Scholars

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

January 1990

Volume

60

Issue

1

Start / End Page

133 / 140

Related Subject Headings

  • Myosins
  • Myosin Subfragments
  • Mutation
  • Muscles
  • Molecular Sequence Data
  • Genes
  • Gene Amplification
  • Developmental Biology
  • Cytoskeleton
  • Codon
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bejsovec, A., & Anderson, P. (1990). Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. Cell, 60(1), 133–140. https://doi.org/10.1016/0092-8674(90)90723-r
Bejsovec, A., and P. Anderson. “Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.Cell 60, no. 1 (January 1990): 133–40. https://doi.org/10.1016/0092-8674(90)90723-r.
Bejsovec, A., and P. Anderson. “Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.Cell, vol. 60, no. 1, Jan. 1990, pp. 133–40. Epmc, doi:10.1016/0092-8674(90)90723-r.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

January 1990

Volume

60

Issue

1

Start / End Page

133 / 140

Related Subject Headings

  • Myosins
  • Myosin Subfragments
  • Mutation
  • Muscles
  • Molecular Sequence Data
  • Genes
  • Gene Amplification
  • Developmental Biology
  • Cytoskeleton
  • Codon