Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.
Journal Article (Journal Article)
Cryoglobulinemia is rarely reported in children, and kidney failure secondary to cryoglobulinemia is even more uncommon. We report the case of a 7-year-old boy with cryoglobulins and a systemic illness, including persistent fever, arthralgias, rash, hypocomplementemia, and acute kidney injury associated with nephritic urine sediment. An extensive workup showed no infectious, neoplastic, or rheumatological cause of his kidney injury. The kidney biopsy specimen showed membranoproliferative glomerulonephritis type 1 with electron microscopic evidence of rhomboid crystalloid inclusions. These inclusions have rarely been reported in adult patients with cryoglobulinemia. The patient underwent spontaneous remission, including full recovery of kidney function, and required no immune suppression. The patient's course is consistent with cryoglobulinemia-associated kidney injury, which supports the inclusion of essential cryoglobulinemia in the differential diagnosis of pediatric patients with hypocomplementemic glomerulonephritis.
Full Text
Duke Authors
Cited Authors
- Nester, CM; Benner, EJ; Latour, M; Nickeleit, V; Hamrick, H; Primack, W
Published Date
- May 2009
Published In
Volume / Issue
- 53 / 5
Start / End Page
- 866 - 870
PubMed ID
- 19303686
Pubmed Central ID
- PMC3050500
Electronic International Standard Serial Number (EISSN)
- 1523-6838
Digital Object Identifier (DOI)
- 10.1053/j.ajkd.2009.01.015
Language
- eng
Conference Location
- United States