Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

Journal Article (Journal Article)

Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.

Full Text

Duke Authors

Cited Authors

  • Benner, EJ; Mosley, RL; Destache, CJ; Lewis, TB; Jackson-Lewis, V; Gorantla, S; Nemachek, C; Green, SR; Przedborski, S; Gendelman, HE

Published Date

  • June 22, 2004

Published In

Volume / Issue

  • 101 / 25

Start / End Page

  • 9435 - 9440

PubMed ID

  • 15197276

Pubmed Central ID

  • PMC438994

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0400569101


  • eng

Conference Location

  • United States