Nanomechanics of streptavidin hubs for molecular materials.

Journal Article (Journal Article)

A new strategy is reported for creating protein-based nanomaterials by genetically fusing large polypeptides to monomeric streptavidin and exploiting the propensity of streptavidin monomers(SM) to self-assemble into stable tetramers. We have characterized the mechanical properties of streptavidin-linked structures and measured, for the first time, the mechanical strength of streptavidin tetramers themselves. Using streptavidin tetramers as molecular hubs offers a unique opportunity to create a variety of well-defined, self-assembled protein-based (nano)materials with unusual mechanical properties.

Full Text

Duke Authors

Cited Authors

  • Kim, M; Wang, C-C; Benedetti, F; Rabbi, M; Bennett, V; Marszalek, PE

Published Date

  • December 15, 2011

Published In

Volume / Issue

  • 23 / 47

Start / End Page

  • 5684 - 5688

PubMed ID

  • 22102445

Pubmed Central ID

  • PMC3837471

Electronic International Standard Serial Number (EISSN)

  • 1521-4095

Digital Object Identifier (DOI)

  • 10.1002/adma.201103316


  • eng

Conference Location

  • Germany