Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.

Journal Article (Journal Article;Review)

The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and force-transducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

Full Text

Duke Authors

Cited Authors

  • Nilsson, KR; Bennett, V

Published Date

  • August 2009

Published In

Volume / Issue

  • 54 / 2

Start / End Page

  • 106 - 115

PubMed ID

  • 19636256

Electronic International Standard Serial Number (EISSN)

  • 1533-4023

Digital Object Identifier (DOI)

  • 10.1097/FJC.0b013e3181b2b6ed


  • eng

Conference Location

  • United States