Being there: cellular targeting of voltage-gated sodium channels in the heart.

Journal Article (Journal Article)

Voltage-gated sodium (Na(v)) channels in cardiomyocytes are localized in specialized membrane domains that optimize their functions in propagating action potentials across cell junctions and in stimulating voltage-gated calcium channels located in T tubules. Mutation of the ankyrin-binding site of Na(v)1.5, the principal Na(v) channel in the heart, was previously known to cause cardiac arrhythmia and the retention of Na(v)1.5 in an intracellular compartment in cardiomyocytes. Conclusive evidence is now provided that direct interaction between Na(v)1.5 and ankyrin-G is necessary for the expression of Na(v)1.5 at the cardiomyocyte cell surface.

Full Text

Duke Authors

Cited Authors

  • Bennett, V; Healy, J

Published Date

  • January 14, 2008

Published In

Volume / Issue

  • 180 / 1

Start / End Page

  • 13 - 15

PubMed ID

  • 18180365

Pubmed Central ID

  • PMC2213601

Electronic International Standard Serial Number (EISSN)

  • 1540-8140

Digital Object Identifier (DOI)

  • 10.1083/jcb.200712098


  • eng

Conference Location

  • United States