Insulin receptor of fat cells in insulin-resistant metabolic states.
Journal Article (Journal Article)
A diminished response to insulin is exhibited by isolated fat cells obtained from rats that have been either starved, or treated with prednisone, or made diabetic by administration of streptozotocin. This decrease in response is not accompanied by changes in the quantity of insulin receptor of these cells or in the affinity of these receptors for insulin. Similarly, the decreased responsiveness to insulin of fat cells obtained from certain species (hamster, rabbit, mouse, guinea pig) is not explainable in terms of alterations of the insulin receptor.
Full Text
Duke Authors
Cited Authors
- Vann Bennett, G; Cuatrecasas, P
Published Date
- May 19, 1972
Published In
Volume / Issue
- 176 / 4036
Start / End Page
- 805 - 806
PubMed ID
- 4260623
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.176.4036.805
Language
- eng
Conference Location
- United States