Insulin receptor of fat cells in insulin-resistant metabolic states.

Journal Article (Journal Article)

A diminished response to insulin is exhibited by isolated fat cells obtained from rats that have been either starved, or treated with prednisone, or made diabetic by administration of streptozotocin. This decrease in response is not accompanied by changes in the quantity of insulin receptor of these cells or in the affinity of these receptors for insulin. Similarly, the decreased responsiveness to insulin of fat cells obtained from certain species (hamster, rabbit, mouse, guinea pig) is not explainable in terms of alterations of the insulin receptor.

Full Text

Duke Authors

Cited Authors

  • Vann Bennett, G; Cuatrecasas, P

Published Date

  • May 19, 1972

Published In

Volume / Issue

  • 176 / 4036

Start / End Page

  • 805 - 806

PubMed ID

  • 4260623

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.176.4036.805

Language

  • eng

Conference Location

  • United States