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The nature of aqueous tunneling pathways between electron-transfer proteins.

Publication ,  Journal Article
Lin, J; Balabin, IA; Beratan, DN
Published in: Science (New York, N.Y.)
November 2005

Structured water molecules near redox cofactors were found recently to accelerate electron-transfer (ET) kinetics in several systems. Theoretical study of interprotein electron transfer across an aqueous interface reveals three distinctive electronic coupling mechanisms that we describe here: (i) a protein-mediated regime when the two proteins are in van der Waals contact; (ii) a structured water-mediated regime featuring anomalously weak distance decay at relatively close protein-protein contact distances; and (iii) a bulk water-mediated regime at large distances. Our analysis explains a range of otherwise puzzling biological ET kinetic data and provides a framework for including explicit water-mediated tunneling effects on ET kinetics.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

November 2005

Volume

310

Issue

5752

Start / End Page

1311 / 1313

Related Subject Headings

  • Water
  • Thermodynamics
  • Protein Conformation
  • Porphyrins
  • Models, Chemical
  • Kinetics
  • General Science & Technology
  • Electron Transport
  • Cytochromes b5
  • Chemistry, Physical
 

Citation

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Lin, J., Balabin, I. A., & Beratan, D. N. (2005). The nature of aqueous tunneling pathways between electron-transfer proteins. Science (New York, N.Y.), 310(5752), 1311–1313. https://doi.org/10.1126/science.1118316
Lin, Jianping, Ilya A. Balabin, and David N. Beratan. “The nature of aqueous tunneling pathways between electron-transfer proteins.Science (New York, N.Y.) 310, no. 5752 (November 2005): 1311–13. https://doi.org/10.1126/science.1118316.
Lin J, Balabin IA, Beratan DN. The nature of aqueous tunneling pathways between electron-transfer proteins. Science (New York, NY). 2005 Nov;310(5752):1311–3.
Lin, Jianping, et al. “The nature of aqueous tunneling pathways between electron-transfer proteins.Science (New York, N.Y.), vol. 310, no. 5752, Nov. 2005, pp. 1311–13. Epmc, doi:10.1126/science.1118316.
Lin J, Balabin IA, Beratan DN. The nature of aqueous tunneling pathways between electron-transfer proteins. Science (New York, NY). 2005 Nov;310(5752):1311–1313.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

November 2005

Volume

310

Issue

5752

Start / End Page

1311 / 1313

Related Subject Headings

  • Water
  • Thermodynamics
  • Protein Conformation
  • Porphyrins
  • Models, Chemical
  • Kinetics
  • General Science & Technology
  • Electron Transport
  • Cytochromes b5
  • Chemistry, Physical