The nature of aqueous tunneling pathways between electron-transfer proteins.

Journal Article (Journal Article)

Structured water molecules near redox cofactors were found recently to accelerate electron-transfer (ET) kinetics in several systems. Theoretical study of interprotein electron transfer across an aqueous interface reveals three distinctive electronic coupling mechanisms that we describe here: (i) a protein-mediated regime when the two proteins are in van der Waals contact; (ii) a structured water-mediated regime featuring anomalously weak distance decay at relatively close protein-protein contact distances; and (iii) a bulk water-mediated regime at large distances. Our analysis explains a range of otherwise puzzling biological ET kinetic data and provides a framework for including explicit water-mediated tunneling effects on ET kinetics.

Full Text

Duke Authors

Cited Authors

  • Lin, J; Balabin, IA; Beratan, DN

Published Date

  • November 2005

Published In

Volume / Issue

  • 310 / 5752

Start / End Page

  • 1311 - 1313

PubMed ID

  • 16311331

Pubmed Central ID

  • PMC3613566

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1118316


  • eng