Skip to main content
Journal cover image

The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer.

Publication ,  Journal Article
Alvarez Secord, A; Sayer, R; Snyder, SA; Broadwater, G; Rodriguez, GC; Berchuck, A; Blackwell, K
Published in: Gynecol Oncol
July 2004

OBJECTIVE: To assess if the angiogenic factors vascular endothelial growth factor (VEGF) and D-dimer are predictive of persistent disease, early relapse, and survival in patients with ovarian cancer who achieve a complete clinical remission after first-line chemotherapy. METHODS: Serum levels of VEGF and D-dimer were assessed by ELISA in 62 patients who completed first-line chemotherapy and underwent second-look laparotomy at Duke University Medical Center. Cox Proportional Hazards Modeling was utilized to determine if VEGF and/or D-dimer levels could predict disease-free and overall survival. The Kaplan-Meier method was used to estimate median survival. The Wilcoxon test was used to determine if a significant difference existed in median VEGF and D-dimer levels between patients with positive and negative second-look operations. RESULTS: Forty (65%) of the 62 women who underwent second-look laparotomy had persistent disease. The median VEGF levels were 264 pg/ml (range 109-896 pg/ml) in the group with negative second looks compared to 390 pg/ml (range 99-1011 pg/ml) in those with positive second-looks (P = 0.1). High levels of VEGF were marginally associated with the presence of persistent (P = 0.10) and gross (P = 0.07) disease at the time of second look laparotomy. After adjusting for CA125, women with high VEGF serum levels had a worse overall survival (P = 0.004). CONCLUSIONS: This study suggests that serum VEGF may be a clinically important marker for persistent disease and is predictive of survival in ovarian cancer patients after first-line chemotherapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

July 2004

Volume

94

Issue

1

Start / End Page

74 / 79

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Second-Look Surgery
  • Retrospective Studies
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Laparotomy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alvarez Secord, A., Sayer, R., Snyder, S. A., Broadwater, G., Rodriguez, G. C., Berchuck, A., & Blackwell, K. (2004). The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer. Gynecol Oncol, 94(1), 74–79. https://doi.org/10.1016/j.ygyno.2004.03.043
Alvarez Secord, Angeles, Robyn Sayer, Stacey A. Snyder, Gloria Broadwater, Gustavo C. Rodriguez, Andrew Berchuck, and Kimberly Blackwell. “The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer.Gynecol Oncol 94, no. 1 (July 2004): 74–79. https://doi.org/10.1016/j.ygyno.2004.03.043.
Alvarez Secord A, Sayer R, Snyder SA, Broadwater G, Rodriguez GC, Berchuck A, et al. The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer. Gynecol Oncol. 2004 Jul;94(1):74–9.
Alvarez Secord, Angeles, et al. “The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer.Gynecol Oncol, vol. 94, no. 1, July 2004, pp. 74–79. Pubmed, doi:10.1016/j.ygyno.2004.03.043.
Alvarez Secord A, Sayer R, Snyder SA, Broadwater G, Rodriguez GC, Berchuck A, Blackwell K. The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer. Gynecol Oncol. 2004 Jul;94(1):74–79.
Journal cover image

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

July 2004

Volume

94

Issue

1

Start / End Page

74 / 79

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Second-Look Surgery
  • Retrospective Studies
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Laparotomy