A case of vanishing bile duct syndrome and IBD secondary to Hodgkin's lymphoma.

Journal Article (Journal Article)

BACKGROUND: A 39-year-old man presented with a 2-month history of abdominal pain, jaundice, non-bloody diarrhea, weakness, and weight loss. Initial evaluation revealed intrahepatic ductopenia consistent with vanishing bile duct syndrome and IBD, type unclassified. Although treatment with budesonide improved his symptoms, they worsened several months later. On repeat evaluation, he was found to have extensive lymphadenopathy and an elevated white blood cell count. INVESTIGATIONS: Physical examination, laboratory investigations, abdominal ultrasound, CT scans, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography, colonoscopies with biopsies, hepatic biopsy, axillary lymph node biopsy. DIAGNOSIS: Hodgkin's lymphoma with secondary vanishing bile duct syndrome and IBD, type unclassified. MANAGEMENT: The initial symptoms were managed with budesonide, but following recurrence, the patient's underlying lymphoma was treated with nitrogen mustard and dexamethasone.

Full Text

Duke Authors

Cited Authors

  • DeBenedet, AT; Berg, CL; Enfield, KB; Woodford, RL; Bennett, AK; Northup, PG

Published Date

  • January 2008

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 49 - 53

PubMed ID

  • 18174907

Electronic International Standard Serial Number (EISSN)

  • 1743-4386

Digital Object Identifier (DOI)

  • 10.1038/ncpgasthep1001


  • eng

Conference Location

  • England