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Identification of a human heme exporter that is essential for erythropoiesis.

Publication ,  Journal Article
Quigley, JG; Yang, Z; Worthington, MT; Phillips, JD; Sabo, KM; Sabath, DE; Berg, CL; Sassa, S; Wood, BL; Abkowitz, JL
Published in: Cell
September 17, 2004

FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. Retroviral interference with FLVCR display results in a loss of erythroid progenitors (colony-forming units-erythroid, CFU-E) and severe anemia in cats. In this report, we demonstrate that human FLVCR exports cytoplasmic heme and hypothesize that human FLVCR is required on developing erythroid cells to protect them from heme toxicity. Inhibition of FLVCR in K562 cells decreases heme export, impairs their erythroid maturation and leads to apoptosis. FLVCR is upregulated on CFU-E, indicating that heme export is important in primary cells at this stage. Studies of FLVCR expression in cell lines suggest this exporter also impacts heme trafficking in intestine and liver. To our knowledge, this is the first description of a mammalian heme transporter.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

September 17, 2004

Volume

118

Issue

6

Start / End Page

757 / 766

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Virus
  • RNA, Messenger
  • Protein Transport
  • Membrane Transport Proteins
  • Liver
  • Intestinal Mucosa
  • Humans
  • Heme
  • Hematopoietic Stem Cells
 

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Quigley, J. G., Yang, Z., Worthington, M. T., Phillips, J. D., Sabo, K. M., Sabath, D. E., … Abkowitz, J. L. (2004). Identification of a human heme exporter that is essential for erythropoiesis. Cell, 118(6), 757–766. https://doi.org/10.1016/j.cell.2004.08.014
Quigley, John G., Zhantao Yang, Mark T. Worthington, John D. Phillips, Kathleen M. Sabo, Daniel E. Sabath, Carl L. Berg, Shigeru Sassa, Brent L. Wood, and Janis L. Abkowitz. “Identification of a human heme exporter that is essential for erythropoiesis.Cell 118, no. 6 (September 17, 2004): 757–66. https://doi.org/10.1016/j.cell.2004.08.014.
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell. 2004 Sep 17;118(6):757–66.
Quigley, John G., et al. “Identification of a human heme exporter that is essential for erythropoiesis.Cell, vol. 118, no. 6, Sept. 2004, pp. 757–66. Pubmed, doi:10.1016/j.cell.2004.08.014.
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL. Identification of a human heme exporter that is essential for erythropoiesis. Cell. 2004 Sep 17;118(6):757–766.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

September 17, 2004

Volume

118

Issue

6

Start / End Page

757 / 766

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Virus
  • RNA, Messenger
  • Protein Transport
  • Membrane Transport Proteins
  • Liver
  • Intestinal Mucosa
  • Humans
  • Heme
  • Hematopoietic Stem Cells