The meaning of genetic research results: reflections from individuals with and without a known genetic disorder.


Journal Article

In the debate about whether to return individual genetic results to research participants, consideration of the nature of results has taken precedence over contextual factors associated with different study designs and populations. We conducted in-depth interviews with 24 individuals who participated in a genotype-driven study of cystic fibrosis: 9 of the individuals had cystic fibrosis, 15 had participated as healthy volunteers, and all had gene variants of interest to the researchers. These interviews revealed that the two groups had different ideas about the meaningfulness of genetic results. Our findings point to the importance of understanding research context, such as participants' relationship with the researcher and whether they have the disease condition under study, when considering whether to return individual results.

Full Text

Cited Authors

  • Cadigan, RJ; Michie, M; Henderson, G; Davis, AM; Beskow, LM

Published Date

  • December 2011

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 30 - 40

PubMed ID

  • 22228058

Pubmed Central ID

  • 22228058

Electronic International Standard Serial Number (EISSN)

  • 1556-2654

International Standard Serial Number (ISSN)

  • 1556-2646

Digital Object Identifier (DOI)

  • 10.1525/jer.2011.6.4.30


  • eng