New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response.
Journal Article (Journal Article;Review)
A small subset of T cells (gamma-delta T cells) is able to recognize phosphoantigens that are overexpressed in some cancer cells and may selectively target and kill cancer cells with high levels of phosphoantigen. Moreover, nitrogen-containing bisphosphonates, such as zoledronic acid, are able to induce accumulation of specific phosphoantigens in some cancer cells. A recent preclinical study showed that gamma-delta T cells effectively targeted and killed zoledronic acid-treated estrogen-receptor-positive breast cancer cells. These new data provide growing insight into a potential mechanism of action for some of the anticancer activity demonstrated by zoledronic acid in breast cancer clinical trials.
Full Text
Duke Authors
Cited Authors
- Hamilton, E; Clay, TM; Blackwell, KL
Published Date
- October 2011
Published In
Volume / Issue
- 29 / 8
Start / End Page
- 533 - 541
PubMed ID
- 21843051
Electronic International Standard Serial Number (EISSN)
- 1532-4192
Digital Object Identifier (DOI)
- 10.3109/07357907.2011.605413
Language
- eng
Conference Location
- England