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Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer.

Publication ,  Journal Article
Nolen, BM; Marks, JR; Ta'san, S; Rand, A; Luong, TM; Wang, Y; Blackwell, K; Lokshin, AE
Published in: Breast Cancer Res
2008

INTRODUCTION: Neoadjuvant chemotherapy has become the standard of care for the diverse population of women diagnosed with locally advanced breast cancer. Serum biomarker levels are increasingly being investigated for their ability to predict therapy response and aid in the development of individualized treatment regimens. Multianalyte profiles may offer greater predictive power for neoadjuvant treatment response than the individual biomarkers currently in use. METHODS: Serum samples were collected from 44 patients enrolled in a phase I-II, open-label study of liposomal doxorubicin and paclitaxel in combination with whole breast hyperthermia for the neoadjuvant treatment of locally advanced breast cancer (stage IIB or stage III). Samples were collected prior to each of four rounds of treatment and prior to definitive surgery. Samples were assayed by Luminex assay for 55 serum biomarkers, including cancer antigens, growth/angiogenic factors, apoptosis-related molecules, metastasis-related molecules, adhesion molecules, adipokines, cytokines, chemokines, hormones, and other proteins. RESULTS: Biomarker levels were compared retrospectively with clinical and pathologic treatment responses. Univariate analysis of the data identified several groups of biomarkers that differed significantly among treatment outcome groups early in the course of neoadjuvant chemotherapy. Multivariate statistical analysis revealed multibiomarker panels that could differentiate between treatment response groups with high sensitivity and specificity. CONCLUSION: We demonstrate here that serum biomarker profiles may offer predictive power concerning treatment response and outcome in the neoadjuvant setting. The continued development of these findings will be of considerable clinical utility in the design of treatment regimens for individual breast cancer patients. TRIAL REGISTRATION: #NCT00346229.

Duke Scholars

Published In

Breast Cancer Res

DOI

EISSN

1465-542X

Publication Date

2008

Volume

10

Issue

3

Start / End Page

R45

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Multivariate Analysis
  • Hyperthermia, Induced
  • Humans
  • Doxorubicin
  • Disease Progression
 

Citation

APA
Chicago
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MLA
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Nolen, B. M., Marks, J. R., Ta’san, S., Rand, A., Luong, T. M., Wang, Y., … Lokshin, A. E. (2008). Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer. Breast Cancer Res, 10(3), R45. https://doi.org/10.1186/bcr2096
Nolen, Brian M., Jeffrey R. Marks, Shlomo Ta’san, Alex Rand, The Minh Luong, Yun Wang, Kimberly Blackwell, and Anna E. Lokshin. “Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer.Breast Cancer Res 10, no. 3 (2008): R45. https://doi.org/10.1186/bcr2096.
Nolen BM, Marks JR, Ta’san S, Rand A, Luong TM, Wang Y, et al. Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer. Breast Cancer Res. 2008;10(3):R45.
Nolen, Brian M., et al. “Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer.Breast Cancer Res, vol. 10, no. 3, 2008, p. R45. Pubmed, doi:10.1186/bcr2096.
Nolen BM, Marks JR, Ta’san S, Rand A, Luong TM, Wang Y, Blackwell K, Lokshin AE. Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer. Breast Cancer Res. 2008;10(3):R45.

Published In

Breast Cancer Res

DOI

EISSN

1465-542X

Publication Date

2008

Volume

10

Issue

3

Start / End Page

R45

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Multivariate Analysis
  • Hyperthermia, Induced
  • Humans
  • Doxorubicin
  • Disease Progression