Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementia


Journal Article

OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewed the 15 randomized controlled trials and one review that fitted predetermined criteria. We included studies that reported the outcomes quality of life, well-being, happiness, or pleasure. MEASUREMENTS: We rated the validity of studies using a checklist. We calculated mean differences between intervention and control groups at follow-up. RESULTS: None of the evaluated trials reported a significant benefit to quality of life or well-being for people with dementia when comparing those taking a drug or its comparator at follow-up (pooled weighted mean difference: 0.18 [95% confidence interval: -0.82 to 0.46]). CONCLUSION: We found no consistent evidence that any drug improves quality of life in people with dementia. We recommend that all dementia trials should include quality of life as an outcome, as this is important to patients, and cannot be presumed from improvements in cognition or other symptomatic outcomes, especially if the latter are small.

Full Text

Duke Authors

Cited Authors

  • Cooper, C; Mukadam, N; Katona, C; Lyketsos, CG; Blazer, D; Ames, D; Rabins, P; Brodaty, H; Lima, CDM; Livingston, G

Published Date

  • January 12, 2012

Published In

Electronic International Standard Serial Number (EISSN)

  • 1545-7214

International Standard Serial Number (ISSN)

  • 1064-7481

Digital Object Identifier (DOI)

  • 10.1097/JGP.0b013e31823e31a2

Citation Source

  • Scopus