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Depressive symptoms in the elderly: association with total white blood cell count.

Publication ,  Journal Article
Brown, SL; Salive, ME; Guralnik, JM; Wallace, RB; Ostfeld, AM; Blazer, D
Published in: Prog Neuropsychopharmacol Biol Psychiatry
September 1995

1. The white blood cell (WBC) count in those with high depressive symptoms and non-depressed participants in the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were compared. 2. Of 3769 participants 10.8% had high depressive symptoms as assessed by the Centers for Epidemiologic Studies Depression (CES-D) Scale. The mean white blood cell count was higher in the high depressive symptoms group compared to the non-depressed group (6.8 +/- 0.12 x 10(9) WBC/1 and 6.5 +/- 0.03 x 10(9) WBC/1, respectively, p < 0.01). 3. Because older adults frequently have disabling chronic conditions which could both influence their leukocyte count and cause depressive symptoms, models were developed which controlled for the potential confounding. Even after adjusting for potential confounders, high depressive symptoms were still associated with higher white blood cell counts.

Duke Scholars

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

September 1995

Volume

19

Issue

5

Start / End Page

849 / 860

Location

England

Related Subject Headings

  • Statistics as Topic
  • Psychiatry
  • Male
  • Linear Models
  • Leukocyte Count
  • Humans
  • Female
  • Disabled Persons
  • Diagnosis, Differential
  • Depressive Disorder
 

Citation

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Brown, S. L., Salive, M. E., Guralnik, J. M., Wallace, R. B., Ostfeld, A. M., & Blazer, D. (1995). Depressive symptoms in the elderly: association with total white blood cell count. Prog Neuropsychopharmacol Biol Psychiatry, 19(5), 849–860. https://doi.org/10.1016/0278-5846(95)00115-c
Brown, S. L., M. E. Salive, J. M. Guralnik, R. B. Wallace, A. M. Ostfeld, and D. Blazer. “Depressive symptoms in the elderly: association with total white blood cell count.Prog Neuropsychopharmacol Biol Psychiatry 19, no. 5 (September 1995): 849–60. https://doi.org/10.1016/0278-5846(95)00115-c.
Brown SL, Salive ME, Guralnik JM, Wallace RB, Ostfeld AM, Blazer D. Depressive symptoms in the elderly: association with total white blood cell count. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):849–60.
Brown, S. L., et al. “Depressive symptoms in the elderly: association with total white blood cell count.Prog Neuropsychopharmacol Biol Psychiatry, vol. 19, no. 5, Sept. 1995, pp. 849–60. Pubmed, doi:10.1016/0278-5846(95)00115-c.
Brown SL, Salive ME, Guralnik JM, Wallace RB, Ostfeld AM, Blazer D. Depressive symptoms in the elderly: association with total white blood cell count. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):849–860.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

September 1995

Volume

19

Issue

5

Start / End Page

849 / 860

Location

England

Related Subject Headings

  • Statistics as Topic
  • Psychiatry
  • Male
  • Linear Models
  • Leukocyte Count
  • Humans
  • Female
  • Disabled Persons
  • Diagnosis, Differential
  • Depressive Disorder