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The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease

Publication ,  Journal Article
Bacon, SL; Sherwood, A; Hinderliter, A; Plourde, A; Pierson, L; Blumenthal, JA
Published in: International Journal of Vascular Medicine
November 19, 2012

Impaired endothelial function has been shown to limit exercise in coronary artery disease (CAD) patients and has been implicated in myocardial ischemia. However, the association of endothelial function and ischemia on peak exercise oxygen consumption (VO2) has not been previously reported. A total of 116 CAD patients underwent standard exercise stress testing, during which VO2 was measured. On a separate day, endothelial-dependent and -independent function were assessed by ultrasound using flow-mediated arterial vasodilation (FMD) and sublingual glyceryl trinitrate administration (GTNMD) of the brachial artery. Patients with exercise-induced myocardial ischemia had lower FMD than nonischemic patients (3.64 ± 0.57 versus 4.98 ± 0.36, P =. 050), but there was no difference in GTNMD (14.11 ± 0.99 versus 15.47 ± 0.63, P =. 249). Analyses revealed that both FMD (P =. 006) and GTNMD (P =. 019) were related to peak VO2. However, neither the presence of ischemia (P =. 860) nor the interaction of ischemia with FMD (P =. 382) and GTNMD (P =. 151) was related to peak VO2. These data suggest that poor endothelial function, potentially via impaired NO production and smooth muscle dysfunction, may be an important determinant of exercise capacity in patients with CAD, independent of myocardial ischemia. © 2012 Simon L. Bacon et al.

Duke Scholars

Published In

International Journal of Vascular Medicine

DOI

EISSN

2090-2832

ISSN

2090-2824

Publication Date

November 19, 2012

Volume

2012
 

Citation

APA
Chicago
ICMJE
MLA
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Bacon, S. L., Sherwood, A., Hinderliter, A., Plourde, A., Pierson, L., & Blumenthal, J. A. (2012). The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease. International Journal of Vascular Medicine, 2012. https://doi.org/10.1155/2012/274381
Bacon, S. L., A. Sherwood, A. Hinderliter, A. Plourde, L. Pierson, and J. A. Blumenthal. “The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease.” International Journal of Vascular Medicine 2012 (November 19, 2012). https://doi.org/10.1155/2012/274381.
Bacon SL, Sherwood A, Hinderliter A, Plourde A, Pierson L, Blumenthal JA. The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease. International Journal of Vascular Medicine. 2012 Nov 19;2012.
Bacon, S. L., et al. “The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease.” International Journal of Vascular Medicine, vol. 2012, Nov. 2012. Scopus, doi:10.1155/2012/274381.
Bacon SL, Sherwood A, Hinderliter A, Plourde A, Pierson L, Blumenthal JA. The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease. International Journal of Vascular Medicine. 2012 Nov 19;2012.

Published In

International Journal of Vascular Medicine

DOI

EISSN

2090-2832

ISSN

2090-2824

Publication Date

November 19, 2012

Volume

2012