Nitric oxide is necessary for visual learning in Octopus vulgaris.

Published

Journal Article

We recently reported that inhibition of nitric oxide synthase (NOS) in Octopus vulgaris by intramuscular injections of an analog of L-arginine, N-omega-nitro-L-arginine methyl ester (L-NAME), blocked touch learning in Octopus vulgaris. The inactive enantiomorph (D-NAME), which had no effect on learning, was used for control. We now report that essentially the same procedures block visual learning in this animal. We used a visual paradigm in which the octopus was trained to respond positively to a smooth black plastic ball 2.5 cm diameter and negatively to a similar white ball, or vice versa. One set of eight animals was trained to the black ball positive, and another set of six to the white ball positive. Each set was trained at different times by two different trainers. We found that a 1 h pretreatment with the nitric oxide synthase inhibitor L-NAME blocks visual learning in Octopus vulgaris in both sets of animals.

Full Text

Duke Authors

Cited Authors

  • Robertson, JD; Bonaventura, J; Kohm, A; Hiscat, M

Published Date

  • December 1996

Published In

Volume / Issue

  • 263 / 1377

Start / End Page

  • 1739 - 1743

PubMed ID

  • 9025316

Pubmed Central ID

  • 9025316

Electronic International Standard Serial Number (EISSN)

  • 1471-2954

International Standard Serial Number (ISSN)

  • 0962-8452

Digital Object Identifier (DOI)

  • 10.1098/rspb.1996.0254

Language

  • eng