Nitric oxide is required for tactile learning in Octopus vulgaris.

Journal Article (Journal Article)

Nitric oxide, produced by nitric oxide synthase in brain tissue, is essential for several different kinds of learning in vertebrates. We present the first evidence that it is also essential for learning in an invertebrate. Intramuscular injections of an inhibitor of the enzyme completely block touch learning in Octopus vulgaris. Eight control animals learned a touch paradigm, but none of eight synthase-inhibited ones learned it.

Full Text

Duke Authors

Cited Authors

  • Robertson, JD; Bonaventura, J; Kohm, AP

Published Date

  • June 1, 1994

Published In

Volume / Issue

  • 256 / 1347

Start / End Page

  • 269 - 273

PubMed ID

  • 7520179

Electronic International Standard Serial Number (EISSN)

  • 1471-2954

International Standard Serial Number (ISSN)

  • 0962-8452

Digital Object Identifier (DOI)

  • 10.1098/rspb.1994.0080


  • eng