Parent-reported social outcomes after treatment for pediatric embryonal tumors: a prospective longitudinal study.

Published

Journal Article

To examine longitudinal parent-reported social outcomes for children treated for pediatric embryonal brain tumors.Patients (N=220) were enrolled onto a multisite clinical treatment protocol. Parents completed the Child Behavior Checklist/6-18 at the time of their child's diagnosis and yearly thereafter. A generalized linear mixed effects model regression approach was used to examine longitudinal changes in parent ratings of social competence, social problems, and withdrawn/depressed behaviors with demographic and treatment factors as covariates.During the 5-year period following diagnosis and treatment, few patients were reported to have clinically elevated scores on measures of social functioning. Mean scores differed significantly from population norms, yet remained within the average range. Several factors associated with unfavorable patterns of change in social functioning were identified. Patients with high-risk treatment status had a greater increase in parent-reported social problems (P=.001) and withdrawn/depressed behaviors (P=.01) over time compared with average-risk patients. Patients with posterior fossa syndrome had greater parent-reported social problems over time (P=.03). Female patients showed higher withdrawn/depressed scores over time compared with male patients (P<.001). Patient intelligence, age at diagnosis, and parent education level also contributed to parent report of social functioning.Results of this study largely suggest positive social adjustment several years after diagnosis and treatment of a pediatric embryonal tumor. However, several factors, including treatment risk status and posterior fossa syndrome, may be important precursors of long-term social outcomes. Future research is needed to elucidate the trajectory of social functioning as these patients transition into adulthood.

Full Text

Duke Authors

Cited Authors

  • Brinkman, TM; Palmer, SL; Chen, S; Zhang, H; Evankovich, K; Swain, MA; Bonner, MJ; Janzen, L; Knight, S; Armstrong, CL; Boyle, R; Gajjar, A

Published Date

  • November 2012

Published In

Volume / Issue

  • 30 / 33

Start / End Page

  • 4134 - 4140

PubMed ID

  • 23071220

Pubmed Central ID

  • 23071220

Electronic International Standard Serial Number (EISSN)

  • 1527-7755

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.40.6702

Language

  • eng