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Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.

Publication ,  Journal Article
Villamizar, NR; Crow, JH; Piacentino, V; DiBernardo, LR; Daneshmand, MA; Bowles, DE; Groh, MA; Milano, CA
Published in: J Thorac Cardiovasc Surg
December 2010

OBJECTIVE: Achieving transmural tissue ablation might be necessary for successful treatment of atrial fibrillation. The purpose of this study was to evaluate the reproducibility of transmural left atrial ablation using a high-intensity focused ultrasound energy system in a calf model. METHODS: Nine heparinized bovines underwent a beating-heart left atrial ablation with a single application of the high-intensity focused ultrasound device. All animals were acutely killed, and the left atrium was fixed in formalin. Protocolized histological sections (5 μm) were obtained throughout each lesion and prepared with Masson trichrome and hematoxylin and eosin staining. Measurements were performed on a total of 359 slides from the 9 lesions. In addition, fresh left atrial tissues from 18 unused human donor hearts that did not meet the criteria for cardiac transplantation were measured at the site where the high-intensity focused ultrasound device is normally applied. RESULTS: Calf left atrial thickness ranged between 2.5 and 20.1 mm, with a mean of 9.10 mm. High-intensity focused ultrasound ablation consistently produced a 100% transmural lesion in left atrial thickness up to 6 mm. In addition, a transmural lesion was observed in 91% of tissues that were up to 10 mm thick and in 85% that were up to 15 mm thick. Human left atrial thickness ranged between 1.2 to 6 mm, with a mean of 3.7 mm. CONCLUSIONS: Calf left atrial thickness in this study was greater than human left atrial thickness. Human left atrial thickness is generally less than 6 mm, and in this range high-intensity focused ultrasound ablation achieved 100% transmurality. These histological results might correlate with a high success rate of atrial fibrillation ablation by using the high-intensity focused ultrasound system.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

DOI

EISSN

1097-685X

Publication Date

December 2010

Volume

140

Issue

6

Start / End Page

1381 / 7.e1

Location

United States

Related Subject Headings

  • Ultrasonic Therapy
  • Transducers
  • Staining and Labeling
  • Respiratory System
  • Reproducibility of Results
  • Humans
  • Heart Atria
  • Cattle
  • Atrial Fibrillation
  • Animals
 

Citation

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Villamizar, N. R., Crow, J. H., Piacentino, V., DiBernardo, L. R., Daneshmand, M. A., Bowles, D. E., … Milano, C. A. (2010). Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model. J Thorac Cardiovasc Surg, 140(6), 1381-7.e1. https://doi.org/10.1016/j.jtcvs.2010.08.029
Villamizar, Nestor R., Jennifer H. Crow, Valentino Piacentino, Louis R. DiBernardo, Mani A. Daneshmand, Dawn E. Bowles, Mark A. Groh, and Carmelo A. Milano. “Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.J Thorac Cardiovasc Surg 140, no. 6 (December 2010): 1381-7.e1. https://doi.org/10.1016/j.jtcvs.2010.08.029.
Villamizar NR, Crow JH, Piacentino V, DiBernardo LR, Daneshmand MA, Bowles DE, et al. Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model. J Thorac Cardiovasc Surg. 2010 Dec;140(6):1381-7.e1.
Villamizar, Nestor R., et al. “Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.J Thorac Cardiovasc Surg, vol. 140, no. 6, Dec. 2010, pp. 1381-7.e1. Pubmed, doi:10.1016/j.jtcvs.2010.08.029.
Villamizar NR, Crow JH, Piacentino V, DiBernardo LR, Daneshmand MA, Bowles DE, Groh MA, Milano CA. Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model. J Thorac Cardiovasc Surg. 2010 Dec;140(6):1381–7.e1.
Journal cover image

Published In

J Thorac Cardiovasc Surg

DOI

EISSN

1097-685X

Publication Date

December 2010

Volume

140

Issue

6

Start / End Page

1381 / 7.e1

Location

United States

Related Subject Headings

  • Ultrasonic Therapy
  • Transducers
  • Staining and Labeling
  • Respiratory System
  • Reproducibility of Results
  • Humans
  • Heart Atria
  • Cattle
  • Atrial Fibrillation
  • Animals