Aligning emission tomography and MRI images by optimizing the emission-tomography image reconstruction objective function


Journal Article

An important approach to reconstruction of PET and SPECT images is to utilize high-resolution information from registered MRI or CT images. Herein, a PET/SPECT image-reconstruction objective function is presented which includes parameters for the alignment between PET/SPECT and MRI/CT. A Levenberg-Marquardt estimation procedure is developed. An anecdotal evaluation is performed with computer-simulated PET/SPECT projection data for a brain phantom. The simulation models a spatial blur of 2 mm FWHM and utilizes 1-mm-wide PET/SPECT voxels. After two iterations, translational alignment errors are well under 0.1 mm and rotational errors are fractions of a degree.

Duke Authors

Cited Authors

  • Bowsher, JE; Delong, DM; Turkington, TG; Jaszczak, RJ

Published Date

  • December 1, 2003

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 2562 - 2565

International Standard Serial Number (ISSN)

  • 1095-7863

Citation Source

  • Scopus