CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer.
Cancer vaccines have demonstrated clinical benefit, however greater efficacy could be achieved by enhancing their immunogenicity. Owing to cancer vaccines depending on uptake and cross-presentation of tumor antigens by antigen-presenting cells (APCs), we hypothesized that greater immunogenicity would accompany strategies that direct antigen to APC-expressed mannose receptors, initiating a pathway increasing class I and II presentation to T cells. CDX-1307 consists of a human monoclonal antibody targeting the mannose receptor, fused to the human chorionic gonadotropin-β chain (hCG-β), a tumor antigen frequently expressed by epithelial cancers including bladder cancer. In Phase I studies of cancer patients, CDX-1307 was well tolerated and induced significant hCG-β-specific cellular and humoral immune responses when co-administered with GM-CSF and the Toll-like receptor agonists resiquimod and poly-ICLC. An ongoing Phase II trial evaluates CDX-1307 in patients with newly diagnosed, resectable, hCG-β-expressing bladder cancer, where low tumor burden and early intervention may provide greater potential for benefit.
Duke Scholars
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Related Subject Headings
- Virology
- Urinary Bladder Neoplasms
- Urinary Bladder
- Treatment Outcome
- T-Lymphocytes
- Recombinant Fusion Proteins
- Receptors, Cell Surface
- Muscles
- Mannose-Binding Lectins
- Mannose Receptor
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Virology
- Urinary Bladder Neoplasms
- Urinary Bladder
- Treatment Outcome
- T-Lymphocytes
- Recombinant Fusion Proteins
- Receptors, Cell Surface
- Muscles
- Mannose-Binding Lectins
- Mannose Receptor