Liver disease in pregnancy.

Published

Journal Article (Review)

Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, Wilson disease, and viral hepatitis may also be seen in pregnancy. Management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy.

Full Text

Duke Authors

Cited Authors

  • Lee, NM; Brady, CW

Published Date

  • February 2009

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 897 - 906

PubMed ID

  • 19248187

Pubmed Central ID

  • 19248187

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

International Standard Serial Number (ISSN)

  • 1007-9327

Digital Object Identifier (DOI)

  • 10.3748/wjg.15.897

Language

  • eng