Raman spectroscopy: Large-aperture raman spectroscopy for quantitative chemometrics


Journal Article

The creation of an inexpensive, mechanically robust, large-aperture Raman spectrometry for quantitative chemometrics is presented. The traditional slit aperture is replaced with a large-aperture pattern of significant complexity, which converts the instrument into a computational sensor. A specific patter is chosen to have mathematical properties that optimized the performance of this processing step. The pattern is designed so that each column of the pattern acts as a virtual slit, measuring the spectrum at high resolution and combining its result with all the other columns to increase the number of collected photons. A data model is constructed, which use a standard partial least-squares algorithm by using measurements made on liquid tissue phantoms spiked with varying concentrations of ethanol. The successful quantitative measurements in a scattering medium represents a significant step on the path toward the eventual clinical application of Raman spectroscopy.

Duke Authors

Cited Authors

  • McCain, ST; Gehm, ME; Wang, Y; Pitsianis, NP; Brady, DJ

Published Date

  • January 1, 2006

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • 42 -

International Standard Serial Number (ISSN)

  • 1047-6938

Citation Source

  • Scopus