Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics.

Journal Article (Journal Article)

OBJECTIVE: To determine if maternal serum interleukin-6 (IL-6) levels remain predictive of funisitis after completion of antibiotic administration in preterm premature rupture of membranes (PPROM). METHODS: A secondary analysis of a prospective cohort study. Daily blood samples obtained from PPROM subjects were analyzed for IL-6 by enzyme-linked immunosorbent assay. Subjects (N = 39) delivered >7 days post admission and were divided into those with and without funisitis. Data were analyzed using Mann-Whitney U test. RESULTS: Maternal serum IL-6 levels obtained 24-48 hours and 48-72 hours before delivery are elevated in PPROM subjects with funisitis compared to those without funisitis (6.3 vs. 2.7 pg/ml, P < 0.03; 6.1 vs. 1.7 pg/ml, P < 0.02). Receiver operator characteristic curve revealed an IL-6 level of 1.98 pg/ml had sensitivity of 86.7%, specificity of 46.7%, positive predictive value of 61.9% and negative predictive value of 77.8%. CONCLUSION: This data suggests that maternal serum IL-6 levels continue to be predictive of PPROM subjects destined to develop funisitis after completion of antibiotics.

Full Text

Duke Authors

Cited Authors

  • Canzoneri, BJ; Grotegut, CA; Swamy, GK; Brancazio, LR; Sinclair, T; Heine, PR; Murtha, AP

Published Date

  • August 2012

Published In

Volume / Issue

  • 25 / 8

Start / End Page

  • 1329 - 1332

PubMed ID

  • 22046977

Electronic International Standard Serial Number (EISSN)

  • 1476-4954

Digital Object Identifier (DOI)

  • 10.3109/14767058.2011.632794


  • eng

Conference Location

  • England