Early intervention: which patients and how early?

Journal Article (Journal Article)

Despite advances in preventive therapy, acute coronary syndromes (ACS) remain a significant cause of morbidity and mortality. Patient risk varies widely along a spectrum from unstable angina to ST-segment elevation myocardial infarctions (STEMIs) and can be estimated using risk prediction algorithms. Estimated risk is useful to select therapeutic options ranging from aggressive medical therapy for patients at low risk to revascularization for high-risk patients in whom bypass or percutaneous coronary intervention (PCI) is feasible. Appropriate timing of an invasive strategy is crucial, with early intervention maximally benefiting the highest-risk patients. Facilitated PCI's role in patients who present with STEMI and the most appropriate timing of interventional therapy in patients at moderate risk after a non-ST-elevation ACS remain the subject of ongoing debate.

Full Text

Duke Authors

Cited Authors

  • Brennan, JM; Petersen, JL

Published Date

  • July 2008

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 303 - 311

PubMed ID

  • 18611365

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-008-0049-6


  • eng

Conference Location

  • United States