Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase

Journal Article

Adenine phosphoribosyltransferase from the protozoan parasite Leishmania donovani has been crystallized in the presence of the substrate Mg2+ -α- D-5-phosphoribosyl-1-pyrophosphate (PRPP) or the product adenosine-5- monophosphate, as well as in the absence of ligand. These crystals belong to the space group P6122 or its enantiomorph P6522, with unit cell dimensions of a = b = 64.0 Å, c = 240.5 Å, α = β = 90°, and γ = 120°. The crystals diffract to 1.9 Å.

Full Text

Duke Authors

Cited Authors

  • Phillips, CL; Ullman, B; Brennan, RG

Published Date

  • 1996

Published In

Volume / Issue

  • 25 / 4

Start / End Page

  • 510 - 513

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0134(199608)25:4<510::AID-PROT11>3.0.CO;2-K