Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.

Journal Article

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

Full Text

Duke Authors

Cited Authors

  • Herickhoff, CD; Wilson, CM; Grant, GA; Britz, GW; Light, ED; Palmeri, ML; Wolf, PD; Smith, SW

Published Date

  • October 2011

Published In

Volume / Issue

  • 37 / 10

Start / End Page

  • 1667 - 1676

PubMed ID

  • 21856073

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2011.06.017

Language

  • eng

Conference Location

  • England