Intracranial dual-mode IVUS and hyperthermia using circular arrays

Journal Article

In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter through burr holes, for 20 MHz imaging, and 2) by testing a modified circular array for therapy potential with 18.5-MHz and 9.0 MHz CW excitation. The imaging transducer's performance was compared to our previous 9 MHz mechanical IVUS prototype. The therapy transducer was driven by CW electrical power, achieving temperature changes reaching +8°C at a depth of 2 mm in human glioblastoma tissue grown on the flank of a mouse. Further hyperthermia trials showed that resistive heating of the transducer was minimal producing a +2°C increase with CW excitation. © 2011 IEEE.

Full Text

Duke Authors

Cited Authors

  • Patel, V; Light, E; Herickhoff, C; Palmeri, M; Grant, G; Britz, G; Wilson, C; Smith, S

Published Date

  • 2011

Published In

Start / End Page

  • 2185 - 2188

International Standard Serial Number (ISSN)

  • 1948-5719

Digital Object Identifier (DOI)

  • 10.1109/ULTSYM.2011.0542