The prevention and treatment of radiotherapy - induced xerostomia.

Journal Article (Journal Article;Review)

Efforts to reduce the severity of postradiotherapy xerostomia include the use of salivary substitutes to gain symptomatic relief, salivary gland stimulants, agents delivered to protect the glands during radiotherapy (RT), and physical means to partially spare the major salivary glands from RT while adequately irradiating tumor targets. These means include advanced RT treatment planning and salivary tissue transfer to nonirradiated areas. The relative potential gain from each of these strategies is discussed in this article. The combination of partial salivary gland sparing and radiation protectors/stimulants may provide additive or synergistic gains in reducing the severity of xerostomia.

Full Text

Duke Authors

Cited Authors

  • Eisbruch, A; Rhodus, N; Rosenthal, D; Murphy, B; Rasch, C; Sonis, S; Scarantino, C; Brizel, D

Published Date

  • July 2003

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 302 - 308

PubMed ID

  • 12903018

International Standard Serial Number (ISSN)

  • 1053-4296

Digital Object Identifier (DOI)

  • 10.1016/S1053-4296(03)00027-4


  • eng

Conference Location

  • United States