How should we measure and report radiotherapy-induced xerostomia?


Journal Article (Review)

Xerostomia is commonly measured and graded using objective measures of major salivary gland output and observer-rated toxicity grading. The separation between the different grades is somewhat ambiguous in the current toxicity grading systems. We propose a new grading system based primarily on the functional deficits associated with xerostomia. Salivary flow rates have been added as a criterion to the grading system, notwithstanding the weak correlation reported in most studies between the symptoms and objective functional measures. In addition to the observer-rated toxicity grading, recording of patient-reported quality of life, using validated instruments, is encouraged.

Full Text

Duke Authors

Cited Authors

  • Eisbruch, A; Rhodus, N; Rosenthal, D; Murphy, B; Rasch, C; Sonis, S; Scarantino, C; Brizel, D

Published Date

  • July 2003

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 226 - 234

PubMed ID

  • 12903012

Pubmed Central ID

  • 12903012

International Standard Serial Number (ISSN)

  • 1053-4296

Digital Object Identifier (DOI)

  • 10.1016/S1053-4296(03)00033-X


  • eng

Conference Location

  • United States