Diffuse reflectance spectral imaging for breast tumor margin assessment

Journal Article

Diffuse reflectance spectroscopy has been previously explored as a promising method for providing real-time visual maps of tissue composition to help surgeons determine breast lumpectomy margins and to ensure the complete removal of a tumor during surgery. We present the simple design, validation, and implementation of a compact and cost-effective spectral imaging system for the application of tumor margin assessment. Our new system consists of a broadband source with bandpass filters for illumination and a fabricated custom 16-pixel photodiode imaging array for the detection of diffuse reflectance. The system prototype was characterized in tissue-mimicking phantoms and has an SNR of greater than 40 dB in phantoms, animals, and human tissue. We show proof-of-concept for performing fast, wide-field spectral imaging with a simple, inexpensive design. The strategy also allows for the scaling to higher pixel number and density in future iterations of the system. © 2012 SPIE.

Full Text

Duke Authors

Cited Authors

  • Lo, JY; Dhar, S; Yu, B; Brooke, MA; Kuech, TF; Jokerst, NM; Ramanujam, N

Published Date

  • 2012

Published In

Volume / Issue

  • 8214 /

International Standard Serial Number (ISSN)

  • 1605-7422

Digital Object Identifier (DOI)

  • 10.1117/12.909259