Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans.


Journal Article

Recessive mutations in three autosomal genes, him-1, him-5 and him-8, cause high levels of X chromosome nondisjunction in hermaphrodites of Caenorhabditis elegans, with no comparable effect on autosomal disjunction. Each of the mutants has reduced levels of X chromosome recombination, correlating with the increase in nondisjunction. However, normal or elevated levels of recombination occur at the end of the X chromosome hypothesized to contain the pairing region (the left end), with recombination levels decreasing in regions approaching the right end. Thus, both the number and the distribution of X chromosome exchange events are altered in these mutants. As a result, the genetic map of the X chromosome in the him mutants exhibits a clustering of genes due to reduced recombination, a feature characteristic of the genetic map of the autosomes in non-mutant animals. We hypothesize that these him genes are needed for some processive event that initiates near the left end of the X chromosome.

Full Text

Duke Authors

Cited Authors

  • Broverman, SA; Meneely, PM

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 136 / 1

Start / End Page

  • 119 - 127

PubMed ID

  • 8138150

Pubmed Central ID

  • 8138150

Electronic International Standard Serial Number (EISSN)

  • 1943-2631

International Standard Serial Number (ISSN)

  • 0016-6731


  • eng