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Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans.

Publication ,  Journal Article
Broverman, SA; Meneely, PM
Published in: Genetics
January 1994

Recessive mutations in three autosomal genes, him-1, him-5 and him-8, cause high levels of X chromosome nondisjunction in hermaphrodites of Caenorhabditis elegans, with no comparable effect on autosomal disjunction. Each of the mutants has reduced levels of X chromosome recombination, correlating with the increase in nondisjunction. However, normal or elevated levels of recombination occur at the end of the X chromosome hypothesized to contain the pairing region (the left end), with recombination levels decreasing in regions approaching the right end. Thus, both the number and the distribution of X chromosome exchange events are altered in these mutants. As a result, the genetic map of the X chromosome in the him mutants exhibits a clustering of genes due to reduced recombination, a feature characteristic of the genetic map of the autosomes in non-mutant animals. We hypothesize that these him genes are needed for some processive event that initiates near the left end of the X chromosome.

Duke Scholars

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

January 1994

Volume

136

Issue

1

Start / End Page

119 / 127

Related Subject Headings

  • X Chromosome
  • Recombination, Genetic
  • Nondisjunction, Genetic
  • Mutation
  • Models, Genetic
  • Genetic Linkage
  • Genetic Complementation Test
  • Genes, Recessive
  • Disorders of Sex Development
  • Developmental Biology
 

Citation

APA
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ICMJE
MLA
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Broverman, S. A., & Meneely, P. M. (1994). Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans. Genetics, 136(1), 119–127. https://doi.org/10.1093/genetics/136.1.119
Broverman, S. A., and P. M. Meneely. “Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans.Genetics 136, no. 1 (January 1994): 119–27. https://doi.org/10.1093/genetics/136.1.119.
Broverman, S. A., and P. M. Meneely. “Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans.Genetics, vol. 136, no. 1, Jan. 1994, pp. 119–27. Epmc, doi:10.1093/genetics/136.1.119.

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

January 1994

Volume

136

Issue

1

Start / End Page

119 / 127

Related Subject Headings

  • X Chromosome
  • Recombination, Genetic
  • Nondisjunction, Genetic
  • Mutation
  • Models, Genetic
  • Genetic Linkage
  • Genetic Complementation Test
  • Genes, Recessive
  • Disorders of Sex Development
  • Developmental Biology