Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Prior reports document macrophage and lymphocyte infiltration with proinflammatory cytokine expression in pathologic intervertebral disc (IVD) tissues. Nevertheless, the role of the Th17 lymphocyte lineage in mediating disc disease remains uninvestigated. We undertook this study to evaluate the immunophenotype of pathologic IVD specimens, including interleukin-17 (IL-17) expression, from surgically obtained IVD tissue and from nondegenerated autopsy control tissue.
Shamji, MF; Setton, LA; Jarvis, W; So, S; Chen, J; Jing, L; Bullock, R; Isaacs, RE; Brown, C; Richardson, WJ
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