Skip to main content

Associations between APOE variants and metabolic traits and the impact of psychological stress.

Publication ,  Journal Article
Iqbal Kring, SI; Barefoot, J; Brummett, BH; Boyle, SH; Siegler, IC; Toubro, S; Hansen, T; Astrup, A; Pedersen, O; Williams, RB; Sørensen, TIA
Published in: PLoS One
January 19, 2011

OBJECTIVE: In a previous study, we observed that associations between APOE rs439401 and metabolic traits were moderated by chronic stress. Thus, in a population of stressed and non-stressed Danish men, we examined whether associations between APOE rs439401 and a panel of metabolic quantitative traits, all metabolic traits which may lead to T2D and CVD were moderated by psychological stress. METHODS: Obese young men (n = 475, BMI ≥ 31.0 kg/m(2)) and a randomly selected control group (n = 709) identified from a population of 141,800 men were re-examined in two surveys (S-46: mean age 46, S-49: mean age 49 years) where anthropometric and biochemical measures were available. Psychological stress factors were assessed by a self-administered 7-item questionnaire. Each item had the possible response categories "yes" and "no" and assessed familial problems and conflicts. Summing positive responses constituted a stress item score, which was then dichotomized into stressed and non-stressed. Logistic regression analysis, applying a recessive genetic model, was used to assess odds ratios (OR) of the associations between APOE rs439401 genotypes and adverse levels of metabolic traits. RESULTS: The APOE rs439401 TT-genotype associated positively with BMI (OR = 1.09 [1.01; 1.17]), waist circumference (OR = 1.09 [1.02; 1.17]) in stressed men at S-46. Positive associations were observed for fasting plasma glucose (OR = 1.42 [1.07; 1.87]), serum triglycerides (OR = 1.41 [1.05; 1.91]) and with fasting plasma insulin (OR = 1.48 [1.05; 2.08]) in stressed men at S-49. Rs439401 TT-genotype also associated positively with surrogate measures of insulin resistance (HOMA-IR; OR = 1.21 [1.03; 1.41]) and inversely with insulin sensitivity (Stumvoll index; OR = 0.90 [0.82; 0.99], BIGTT-S(I); OR = 0.60 [0.43; 0.85]) in stressed men. No significant associations were observed in non-stressed men, albeit the estimates showed similar but weaker trends as in stressed men. CONCLUSION: The present results suggest that the APOE rs439401 TT-genotype is associated with an adverse metabolic profile in a population of psychologically stressed Danish men.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

January 19, 2011

Volume

6

Issue

1

Start / End Page

e15745

Location

United States

Related Subject Headings

  • Triglycerides
  • Surveys and Questionnaires
  • Stress, Psychological
  • Polymorphism, Single Nucleotide
  • Obesity
  • Middle Aged
  • Metabolism
  • Male
  • Insulin Resistance
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iqbal Kring, S. I., Barefoot, J., Brummett, B. H., Boyle, S. H., Siegler, I. C., Toubro, S., … Sørensen, T. I. A. (2011). Associations between APOE variants and metabolic traits and the impact of psychological stress. PLoS One, 6(1), e15745. https://doi.org/10.1371/journal.pone.0015745
Iqbal Kring, Sofia I., John Barefoot, Beverly H. Brummett, Stephen H. Boyle, Ilene C. Siegler, Søren Toubro, Torben Hansen, et al. “Associations between APOE variants and metabolic traits and the impact of psychological stress.PLoS One 6, no. 1 (January 19, 2011): e15745. https://doi.org/10.1371/journal.pone.0015745.
Iqbal Kring SI, Barefoot J, Brummett BH, Boyle SH, Siegler IC, Toubro S, et al. Associations between APOE variants and metabolic traits and the impact of psychological stress. PLoS One. 2011 Jan 19;6(1):e15745.
Iqbal Kring, Sofia I., et al. “Associations between APOE variants and metabolic traits and the impact of psychological stress.PLoS One, vol. 6, no. 1, Jan. 2011, p. e15745. Pubmed, doi:10.1371/journal.pone.0015745.
Iqbal Kring SI, Barefoot J, Brummett BH, Boyle SH, Siegler IC, Toubro S, Hansen T, Astrup A, Pedersen O, Williams RB, Sørensen TIA. Associations between APOE variants and metabolic traits and the impact of psychological stress. PLoS One. 2011 Jan 19;6(1):e15745.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

January 19, 2011

Volume

6

Issue

1

Start / End Page

e15745

Location

United States

Related Subject Headings

  • Triglycerides
  • Surveys and Questionnaires
  • Stress, Psychological
  • Polymorphism, Single Nucleotide
  • Obesity
  • Middle Aged
  • Metabolism
  • Male
  • Insulin Resistance
  • Humans