A randomized clinical trial comparing contact lens with intraocular lens correction of monocular aphakia during infancy: grating acuity and adverse events at age 1 year.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVE: To compare the visual outcomes and adverse events of contact lens with primary intraocular lens (IOL) correction of monocular aphakia during infancy. METHODS: In a randomized, multicenter (12 sites) clinical trial, 114 infants with a unilateral congenital cataract were assigned to undergo cataract surgery between 1 to 6 months of age either with or without primary IOL implantation. Contact lenses were used to correct aphakia in patients who did not receive IOLs. Grating visual acuity was tested at 1 year of age by a masked traveling examiner. MAIN OUTCOME MEASURE: Grating visual acuity at 1 year of age. RESULTS: The median logMAR visual acuity was not significantly different between the treated eyes in the 2 groups (contact lens group, 0.80; IOL group, 0.97; P = .19). More patients in the IOL group underwent 1 or more additional intraocular operations than patients in the contact lens group (63% vs 12%; P < .001). Most of these additional operations were performed to clear lens reproliferation and pupillary membranes from the visual axis. CONCLUSIONS: There was no statistically significant difference in grating visual acuity at age 1 year between the IOL and contact lens groups; however, additional intraocular operations were performed more frequently in the IOL group. APPLICATION TO CLINICAL PRACTICE: Until longer-term follow-up data are available, caution should be exercised when performing IOL implantation in children aged 6 months or younger given the higher incidence of adverse events and the absence of an improved short-term visual outcome compared with contact lens use.

Full Text

Duke Authors

Cited Authors

  • Infant Aphakia Treatment Study Group, ; Lambert, SR; Buckley, EG; Drews-Botsch, C; DuBois, L; Hartmann, EE; Lynn, MJ; Plager, DA; Wilson, ME

Published Date

  • July 2010

Published In

Volume / Issue

  • 128 / 7

Start / End Page

  • 810 - 818

PubMed ID

  • 20457949

Pubmed Central ID

  • PMC3512571

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

Digital Object Identifier (DOI)

  • 10.1001/archophthalmol.2010.101


  • eng

Conference Location

  • United States