Visual function at baseline and 1 month in acute optic neuritis: predictors of visual outcome.


Journal Article

OBJECTIVE: To identify cutpoints for visual measures at baseline and 1 month predictive of abnormal 6-month vision that could be used as eligibility criteria in a clinical trial to test potential neuroprotection or myelin repair agents in patients with optic neuritis. To determine whether moderate-to-severe dysfunction in one or more visual measures at baseline or 1 month correlates with having major vision loss at 6 months. METHODS: We used the Optic Neuritis Treatment Trial database to evaluate various cutpoints for baseline and 1-month vision levels that predicted abnormal 6-month vision. For selected cutpoints, we computed a 95% CI for positive predictive value and the required sample size if the cutpoint was to be used for clinical trial eligibility. We evaluated whether the degree of visual loss at baseline, 1 month, or change in visual function from baseline to 1 month correlated with 6-month visual acuity, contrast sensitivity, or threshold visual field. RESULTS: The best cutpoints for baseline and 1 month were visual acuity

Full Text

Duke Authors

Cited Authors

  • Kupersmith, MJ; Gal, RL; Beck, RW; Xing, D; Miller, N; Optic Neuritis Study Group,

Duke Contributors

Published Date

  • August 7, 2007

Published In

Volume / Issue

  • 69 / 6

Start / End Page

  • 508 - 514

PubMed ID

  • 17679669

Pubmed Central ID

  • 17679669

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000267272.60714.42


  • eng

Conference Location

  • United States