Development of myopia in infants with birth weights less than 1251 grams. The Cryotherapy for Retinopathy of Prematurity Cooperative Group.


Journal Article

The authors report on the incidence of myopia in a large group of premature infants with birth weights of less than 1251 g followed as part of the multicenter study of Cryotherapy for Retinopathy of Prematurity. None of the eyes reported here underwent cryotherapy. Eyes were refracted using cycloplegic retinoscopy at 3 months (n = 2916), 12 months (n = 2626), and 24 months (n = 961 at 5 of the 23 centers) after term. Myopia was observed in approximately 20% of the children at each test age. The percentage of high myopia (greater than or equal to 5 diopters) doubled from 2% to 4.6% between 3 and 12 months and remained stable thereafter. Lower birth weight and increasing severity of retinopathy of prematurity (ROP) were strong predictors of myopia and high myopia. In addition, anisometropia, astigmatism, and the presence of posterior pole residua from ROP also were associated with a higher incidence of myopia and high myopia.

Full Text

Duke Authors

Cited Authors

  • Quinn, GE; Dobson, V; Repka, MX; Reynolds, J; Kivlin, J; Davis, B; Buckley, E; Flynn, JT; Palmer, EA

Published Date

  • March 1992

Published In

Volume / Issue

  • 99 / 3

Start / End Page

  • 329 - 340

PubMed ID

  • 1565444

Pubmed Central ID

  • 1565444

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(92)31968-2


  • eng

Conference Location

  • United States