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Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes.

Publication ,  Journal Article
O'Laughlin, S; Braverman, M; Smith-Jefferies, M; Buckley, P
Published in: Hum Pathol
December 1992

The purpose of this study was to determine whether human tissue macrophages (M phi s) in various inflammatory/reactive conditions express different immunophenotypes. Using a large panel of monoclonal antibodies to monocyte/M phi-related antigens and a frozen-section immunoperoxidase technique, the following conditions were studied: granulomatous inflammation of unknown etiology, sarcoidosis, cat-scratch fever, toxoplasmosis, Gaucher's disease, and juvenile xanthogranulomas. The results show that there is immunophenotypic variation of the M phi s among the various inflammatory/reactive conditions. For example, the M phi s in cat-scratch fever are nearly unique in the expression of the "early inflammation" antigen identified by antibody 27E10, and the M phi s in juvenile xanthogranulomas, unlike those in most of the other conditions, lacked the antigen detected by antibody 25F9. The M phi s in Gaucher's disease differed from those in the other disorders by the combined absence of CD11b, CD14, G16/1, CD1a, CD25, and CD30. The inflammatory/reactive M phi s also exhibited differences from those in "normal" tissues, namely, a tendency toward acquisition of the antigens identified by antibodies Mac 387 and G16/1 and the more uniform expression of the "activation" antigens CD25, CD30, and CD71. The antigenic variations described here probably reflect differences in antigenic stimuli and M phi function. In addition to the possible biologic implications, this M phi immunophenotypic diversity may have practical diagnostic applications.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

December 1992

Volume

23

Issue

12

Start / End Page

1410 / 1418

Location

United States

Related Subject Headings

  • Xanthogranuloma, Juvenile
  • Toxoplasmosis
  • Sarcoidosis
  • Receptors, Transferrin
  • Receptors, Interleukin-2
  • Phenotype
  • Pathology
  • Macrophages
  • Lymph Nodes
  • Ki-1 Antigen
 

Citation

APA
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ICMJE
MLA
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O’Laughlin, S., Braverman, M., Smith-Jefferies, M., & Buckley, P. (1992). Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes. Hum Pathol, 23(12), 1410–1418. https://doi.org/10.1016/0046-8177(92)90062-8
O’Laughlin, S., M. Braverman, M. Smith-Jefferies, and P. Buckley. “Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes.Hum Pathol 23, no. 12 (December 1992): 1410–18. https://doi.org/10.1016/0046-8177(92)90062-8.
O’Laughlin S, Braverman M, Smith-Jefferies M, Buckley P. Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes. Hum Pathol. 1992 Dec;23(12):1410–8.
O’Laughlin, S., et al. “Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes.Hum Pathol, vol. 23, no. 12, Dec. 1992, pp. 1410–18. Pubmed, doi:10.1016/0046-8177(92)90062-8.
O’Laughlin S, Braverman M, Smith-Jefferies M, Buckley P. Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes. Hum Pathol. 1992 Dec;23(12):1410–1418.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

December 1992

Volume

23

Issue

12

Start / End Page

1410 / 1418

Location

United States

Related Subject Headings

  • Xanthogranuloma, Juvenile
  • Toxoplasmosis
  • Sarcoidosis
  • Receptors, Transferrin
  • Receptors, Interleukin-2
  • Phenotype
  • Pathology
  • Macrophages
  • Lymph Nodes
  • Ki-1 Antigen