Correlations of unique clinical, immunotypic, and histologic findings in cutaneous gamma/delta T-cell lymphoma.
Journal Article
Cutaneous T-cell lymphoma is a malignancy of T cells that express a clone-specific heterodimer T-cell receptor for antigen. The second recognized case of an epidermotropic malignancy of T-cells expressing gamma/delta T-cell receptor-expressing cells is reported. The immunophenotype of the malignant T-cells was CD3+, CD2+, CD7+, gamma/delta T-cell receptor+, CD4-, CD8-, and alpha/beta T-cell receptor-. The clinical features were remarkable for extreme epidermotropism with a scant dermal lymphomatous infiltrate. Profound keratinocyte necrosis occurred in areas of malignant skin infiltrates. Despite cutaneous lesions covering more than 50% of the skin surface of the patient, no adenopathy or splenomegaly was detected. The intense epidermotropism of this patient's gamma/delta T-cell receptor-expressing cells and the putative cytolytic properties of CD4- CD8- gamma/delta contributed to the destruction of epidermis. Remission was induced with a combination of electron beam and extracorporeal photochemotherapy.
Full Text
Duke Authors
Cited Authors
- Heald, P; Buckley, P; Gilliam, A; Perez, M; Knobler, R; Kacinski, B; Edelson, R
Published Date
- May 1992
Published In
Volume / Issue
- 26 / 5 Pt 2
Start / End Page
- 865 - 870
PubMed ID
- 1377210
Pubmed Central ID
- 1377210
International Standard Serial Number (ISSN)
- 0190-9622
Digital Object Identifier (DOI)
- 10.1016/0190-9622(92)70125-y
Language
- eng
Conference Location
- United States