Infection of T but not B lymphocytes by cytomegalovirus in lymph node. An immunophenotypic study.

Published

Journal Article

A 45-year-old black man presented with fever, night sweats, weight loss, and cervical lymphadenopathy. Biopsy of an enlarged node showed partial effacement of the nodal architecture by numerous cells with typical cytomegalovirus (CMV) inclusions. These were also seen by electron microscopy. CMV titers were not elevated, and he tested negative for HIV. An immunophenotypic study done on both paraffin-embedded and frozen tissue showed that the infected cells were of T-lymphocyte phenotype. These cells were remarkable for the lack of HLA-DR and IL-2R antigens, which were expressed by numerous neighboring apparently uninfected cells. The lack of HLA-DR and IL-2R expression by CMV-infected T lymphocytes may be one of the mechanism by which CMV causes immunosuppression.

Full Text

Duke Authors

Cited Authors

  • Younes, M; Podesta, A; Helie, M; Buckley, P

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 75 - 80

PubMed ID

  • 1845924

Pubmed Central ID

  • 1845924

International Standard Serial Number (ISSN)

  • 0147-5185

Digital Object Identifier (DOI)

  • 10.1097/00000478-199101000-00009

Language

  • eng

Conference Location

  • United States