Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes.


Journal Article

The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

Full Text

Duke Authors

Cited Authors

  • Komp, DM; McNamara, J; Buckley, P

Published Date

  • June 1989

Published In

Volume / Issue

  • 73 / 8

Start / End Page

  • 2128 - 2132

PubMed ID

  • 2786434

Pubmed Central ID

  • 2786434

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States