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Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes.

Publication ,  Journal Article
Komp, DM; McNamara, J; Buckley, P
Published in: Blood
June 1989

The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

June 1989

Volume

73

Issue

8

Start / End Page

2128 / 2132

Location

United States

Related Subject Headings

  • Syndrome
  • Receptors, Interleukin-2
  • Placenta
  • Phagocytosis
  • Macrophages
  • Lymphatic Diseases
  • Infectious Mononucleosis
  • Infant, Newborn
  • Infant
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Komp, D. M., McNamara, J., & Buckley, P. (1989). Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. Blood, 73(8), 2128–2132.
Komp, D. M., J. McNamara, and P. Buckley. “Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes.Blood 73, no. 8 (June 1989): 2128–32.
Komp DM, McNamara J, Buckley P. Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. Blood. 1989 Jun;73(8):2128–32.
Komp, D. M., et al. “Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes.Blood, vol. 73, no. 8, June 1989, pp. 2128–32.
Komp DM, McNamara J, Buckley P. Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. Blood. 1989 Jun;73(8):2128–2132.

Published In

Blood

ISSN

0006-4971

Publication Date

June 1989

Volume

73

Issue

8

Start / End Page

2128 / 2132

Location

United States

Related Subject Headings

  • Syndrome
  • Receptors, Interleukin-2
  • Placenta
  • Phagocytosis
  • Macrophages
  • Lymphatic Diseases
  • Infectious Mononucleosis
  • Infant, Newborn
  • Infant
  • Immunology