Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene.

Journal Article

A patient had progressive disseminated coccidioidomycosis and depressed cellular immunity to Coccidioides immitis. He developed a large nasal coccidioidal lesion that was unresponsive to conventional therapy. Application of dinitrochlorobenzene (DNCB) to the nasal lesion was temporally associated with resolution of the lesion and stabilization of the systemic disease. In addition, DNCB application was followed by signs of cellular immunity to C. immitis. These included development of delayed cutaneous hypersensitivity to coccidioidin, as well as lymphokine production and lymphoproliferative responses to coccidioidin. Similar forms of DNCB immunotherapy may prove useful in other patients with fungal disease and depressed cellular immunity.

Full Text

Duke Authors

Cited Authors

  • Burch, WM; Snyderman, R

Published Date

  • March 1982

Published In

Volume / Issue

  • 96 / 3

Start / End Page

  • 329 - 331

PubMed ID

  • 7059096

Pubmed Central ID

  • 7059096

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-96-3-329


  • eng

Conference Location

  • United States