A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

Journal Article (Journal Article)

There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been following an initial cohort of 5,092 seniors since 1995, has reported among its major findings the role of the Apolipoprotein E gene on modifying the risk for Alzheimer's disease (AD) in males and females and identifying pharmacologic compounds that may act to reduce AD risk. This article summarizes the major findings of the Cache County study to date, describes ongoing investigations, and reports preliminary analyses on the outcome of the oldest-old in this population, the subgroup of participants who were over age 84 at the study's inception.

Full Text

Duke Authors

Cited Authors

  • Tschanz, JT; Treiber, K; Norton, MC; Welsh-Bohmer, KA; Toone, L; Zandi, PP; Szekely, CA; Lyketsos, C; Breitner, JCS; Cache County Study Group,

Published Date

  • 2005

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 107 - 114

PubMed ID

  • 16544872

International Standard Serial Number (ISSN)

  • 1521-0987

Digital Object Identifier (DOI)

  • 10.1891/cmaj.6.2.107


  • eng

Conference Location

  • United States