Functional cardiac tissue engineering.

Journal Article (Review;Journal Article)

Heart attack remains the leading cause of death in both men and women worldwide. Stem cell-based therapies, including the use of engineered cardiac tissues, have the potential to treat the massive cell loss and pathological remodeling resulting from heart attack. Specifically, embryonic and induced pluripotent stem cells are a promising source for generation of therapeutically relevant numbers of functional cardiomyocytes and engineering of cardiac tissues in vitro. This review will describe methodologies for successful differentiation of pluripotent stem cells towards the cardiovascular cell lineages as they pertain to the field of cardiac tissue engineering. The emphasis will be placed on comparing the functional maturation in engineered cardiac tissues and developing heart and on methods to quantify cardiac electrical and mechanical function at different spatial scales.

Full Text

Duke Authors

Cited Authors

  • Liau, B; Zhang, D; Bursac, N

Published Date

  • March 2012

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 187 - 206

PubMed ID

  • 22397609

Pubmed Central ID

  • PMC3616389

Electronic International Standard Serial Number (EISSN)

  • 1746-076X

International Standard Serial Number (ISSN)

  • 1746-0751

Digital Object Identifier (DOI)

  • 10.2217/rme.11.122


  • eng