Characterizing functional stem cell-cardiomyocyte interactions.

Journal Article (Review;Journal Article)

Despite the progress in traditional pharmacological and organ transplantation therapies, heart failure still afflicts 5.3 million Americans. Since June 2000, stem cell-based approaches for the prevention and treatment of heart failure have been pursued in clinics with great excitement; however, the exact mechanisms of how transplanted cells improve heart function remain elusive. One of the main difficulties in answering these questions is the limited ability to directly access and study interactions between implanted cells and host cardiomyocytes in situ. With the growing number of candidate cell types for potential clinical use, it is becoming increasingly more important to establish standardized, well-controlled in vitro and in situ assays to compare the efficacy and safety of different stem cells in cardiac repair. This article describes recent innovative methodologies to characterize direct functional interactions between stem cells and cardiomyocytes, aimed to facilitate the rational design of future cell-based therapies for heart disease.

Full Text

Duke Authors

Cited Authors

  • Bursac, N; Kirkton, RD; McSpadden, LC; Liau, B

Published Date

  • January 2010

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 87 - 105

PubMed ID

  • 20017697

Pubmed Central ID

  • PMC2819199

Electronic International Standard Serial Number (EISSN)

  • 1746-076X

International Standard Serial Number (ISSN)

  • 1746-0751

Digital Object Identifier (DOI)

  • 10.2217/rme.09.69

Language

  • eng