Vitamin D receptor gene as a candidate gene for Parkinson disease.

Published

Journal Article

Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and genetic factors in neurodegeneration disorders including multiple sclerosis (MS), Alzheimer disease (AD), and recently Parkinson disease (PD). Given the sparse data on PD, we conducted a two-stage study to evaluate the genetic effects of VDR in PD. In the discovery stage, 30 tagSNPs in VDR were tested for association with risk as a discrete trait and age-at-onset (AAO) as a quantitative trait in 770 Caucasian PD families. In the validation stage, 18 VDR SNPs were tested in an independent Caucasian cohort (267 cases and 267 controls) constructed from a genome-wide association study (GWAS). In the discovery dataset, SNPs in the 5' end of VDR were associated with both risk and AAO with more significant evidence of association with AAO (P= 0.0008-0.02). These 5' SNPs were also associated with AD in another study. In the validation dataset, SNPs in the 3' end of VDR were associated with AAO (P= 0.003) but not risk. The 3' end SNP has been associated with both MS and AD in previous studies. Our findings suggest VDR as a potential susceptibility gene and support an essential role of vitamin D in PD.

Full Text

Cited Authors

  • Butler, MW; Burt, A; Edwards, TL; Zuchner, S; Scott, WK; Martin, ER; Vance, JM; Wang, L

Published Date

  • March 2011

Published In

Volume / Issue

  • 75 / 2

Start / End Page

  • 201 - 210

PubMed ID

  • 21309754

Pubmed Central ID

  • 21309754

Electronic International Standard Serial Number (EISSN)

  • 1469-1809

International Standard Serial Number (ISSN)

  • 0003-4800

Digital Object Identifier (DOI)

  • 10.1111/j.1469-1809.2010.00631.x

Language

  • eng