Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction.

Published

Journal Article (Review)

We review evidence for two models of hemispheric asymmetry and aging: the right hemi-aging model, which proposes that the right hemisphere shows greater age-related decline than the left hemisphere, and the hemispheric asymmetry reduction in old adults (HAROLD) model, which proposes that frontal activity during cognitive performance tends to be less lateralized in older than in younger adults. The right hemi-aging model is supported by behavioral studies in the domains of cognitive, affective, and sensorimotor processing, but the evidence has been mixed. In contrast, available evidence is generally consistent with the HAROLD model, which is supported primarily by functional neuroimaging evidence in the domains of episodic memory encoding and retrieval, semantic memory retrieval, working memory, perception, and inhibitory control. Age-related asymmetry reductions may reflect functional compensation or dedifferentiation, and the evidence, although scarce, tends to support the compensation hypothesis. The right hemi-aging and the HAROLD models are not incompatible. For example, the latter may apply to prefrontal regions and the former to other brain regions.

Full Text

Duke Authors

Cited Authors

  • Dolcos, F; Rice, HJ; Cabeza, R

Published Date

  • November 2002

Published In

Volume / Issue

  • 26 / 7

Start / End Page

  • 819 - 825

PubMed ID

  • 12470693

Pubmed Central ID

  • 12470693

Electronic International Standard Serial Number (EISSN)

  • 1873-7528

International Standard Serial Number (ISSN)

  • 0149-7634

Digital Object Identifier (DOI)

  • 10.1016/s0149-7634(02)00068-4

Language

  • eng