Skip to main content
Journal cover image

Pulmonary kinematics from tagged hyperpolarized helium-3 MRI.

Publication ,  Journal Article
Tustison, NJ; Awate, SP; Cai, J; Altes, TA; Miller, GW; de Lange, EE; Mugler, JP; Gee, JC
Published in: J Magn Reson Imaging
May 2010

PURPOSE: To propose and test the feasibility of a novel method for quantifying 3D regional pulmonary kinematics from hyperpolarized helium-3 tagged MRI in human subjects using a tailored image processing pipeline and a recently developed nonrigid registration framework. MATERIALS AND METHODS: Following image acquisition, inspiratory and expiratory tagged (3)He magnetic resonance (MR) images were preprocessed using various image filtering techniques to enhance the tag surfaces. Segmentation of the three orthogonal sets of tag planes in each lung produced distinct point-set representations of the tag surfaces. Using these labeled point-sets, deformation fields and corresponding strain maps were obtained via nonrigid point-set registration. Kinematic analysis was performed on three volunteers. RESULTS: Tag lines in inspiratory and expiratory images were coregistered producing a continuous 3D correspondence mapping. Average displacement and directional strains were calculated in three subjects in the inferior, mid, and superior portions of the right and left lungs. As expected, the predominant direction of displacements with expiration is from inferior to superior. CONCLUSION: Kinematic quantitation of pulmonary motion using tagged (3)He MRI is feasible using the applied image preprocessing filtering techniques and nonrigid point-set registration. Potential benefits from regional pulmonary kinematic quantitation include the facilitation of diagnosis and local assessment of disease progression.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

May 2010

Volume

31

Issue

5

Start / End Page

1236 / 1241

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Respiratory Function Tests
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Humans
  • Helium
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tustison, N. J., Awate, S. P., Cai, J., Altes, T. A., Miller, G. W., de Lange, E. E., … Gee, J. C. (2010). Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. J Magn Reson Imaging, 31(5), 1236–1241. https://doi.org/10.1002/jmri.22137
Tustison, Nicholas J., Suyash P. Awate, Jing Cai, Talissa A. Altes, G Wilson Miller, Eduard E. de Lange, John P. Mugler, and James C. Gee. “Pulmonary kinematics from tagged hyperpolarized helium-3 MRI.J Magn Reson Imaging 31, no. 5 (May 2010): 1236–41. https://doi.org/10.1002/jmri.22137.
Tustison NJ, Awate SP, Cai J, Altes TA, Miller GW, de Lange EE, et al. Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. J Magn Reson Imaging. 2010 May;31(5):1236–41.
Tustison, Nicholas J., et al. “Pulmonary kinematics from tagged hyperpolarized helium-3 MRI.J Magn Reson Imaging, vol. 31, no. 5, May 2010, pp. 1236–41. Pubmed, doi:10.1002/jmri.22137.
Tustison NJ, Awate SP, Cai J, Altes TA, Miller GW, de Lange EE, Mugler JP, Gee JC. Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. J Magn Reson Imaging. 2010 May;31(5):1236–1241.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

May 2010

Volume

31

Issue

5

Start / End Page

1236 / 1241

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Respiratory Function Tests
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Humans
  • Helium